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Flexeril 5 mg And Ibuprofen: Interactions And More You Need To Know

Is it Safe to Take Flexeril and Ibuprofen at the Same Time?
Flexeril 5 mg and ibuprofen
Nonsteroidal anti-inflammatory drugs
Flexeril 5 mg
Skeletal muscle relaxants
Flexeril and ibuprofen interaction

Flexeril 5 mg is prescribed for painful muscle spasms and Ibuprofen is a commonly used painkiller produced in the market. It is used for treating several conditions mentioned below:


  1. Ease pain and swelling caused by sprains like a sports injury.
  2. Easing inflammation due to conditions such as osteoarthritis.
  3. Easing toothache, and period pains.


Flexeril 5 mg is part of the class of drugs known as skeletal muscle relaxants. On the other hand, Ibuprofen belongs to a group of painkillers called Nonsteroidal anti-inflammatory drugs. 


Ibuprofen is a commonly used medication for pain, inflammation, and fever. This medicine was patented in 1961 and was the first available over-the-counter NSAID.

Flexeril 5 mg and Ibuprofen

Some studies show that the muscle relaxant, Flexeril 5 mg is equally effective when taken with ibuprofen or even without it. 

Flexeril is a prescription drug and provides immense relief from muscle spasms. It is a short-term medication that relieves tension in the muscles. There are warnings and precautions attached to the intake of this drug. 

Combination therapy includes the use of a muscle relaxant and an NSAID. Patients who suffer from lower back pain seem to benefit from this kind of combination therapy. 

Cyclobenzaprine is a widely studied medication and has proven to be effective in the treatment of several musculoskeletal conditions.


There are common and uncommon side effects of Flexeril and they are stated below:

  1. Swelling of face, lips, or the tongue
  2. Difficulty in breathing
  3. Muscle stiffness
  4. Headache
  5. Upset stomach, and 
  6. Agitation

The side effects of ibuprofen are categorized into common and uncommon. 

  1. Dizziness
  2. Nervousness
  3. Weight gain without explanation
  4. Quicker heartbeats
  5. Nausea and vomiting, and 
  6. Confusion

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Nonsteroidal anti-inflammatory drugs

It is necessary to define the term nonsteroidal anti-inflammatory drug. This is the starting point of the discussion on this class of drugs. Once we understand the definition, we move on to the uses of this medication.

These medicines are well-known for the role they play in the reduction of swelling or inflammation. The causes of long-term pain are also cured with the help of these medications. 

Like any other medication, NSAIDs are also available in various forms- creams, gels, tablets, capsules, and injections. Ibuprofen is an anti-inflammatory medicine that cures a plethora of ailments. 

It is best to consult the doctor before taking this medicine and even before stopping. Individuals who have heart problems and kidney problems should refrain from the use. 

It is believed that over-the-counter NSAIDs have fewer side effects than prescription medicines. There is a possibility of side effects with these medications as well. Some of them include:

  • Headaches
  • Drowsiness
  • Indigestion, and
  • Allergic reactions

Flexeril 5 mg

An injury can occur in any part of our bodies. The injuries that one sustains can result in either short-term or long-term pain. The discomfort that accompanies a sprain or a muscular injury is treated with Flexeril 5 mg. 

Flexeril is thought to be less addictive than the other painkillers available for use in the market. No benefits are achieved when flexeril is taken for a longer period, therefore it is given for a short time. 

It helps inhibit pain in the nervous system and works by decreasing the pain in the first two weeks. The recommended dose of flexeril is 10 mg three times a day. The doctor decides on the changes to be made to the doses. 

An individual’s capacity to withstand the dose prescribed is evaluated first before making the necessary changes to the dosage. The dosage of flexeril (cyclobenzaprine) is dependent on the condition that it is prescribed.  

A dose of flexeril stays in the system for about four to six hours. The effect of this medicine happens within an hour of its intake.

Skeletal muscle relaxants

Skeletal muscle relaxants are medications that aid in resolving the pain caused by musculoskeletal disorders. They work in various ways to relax the muscles of our body. 

In addition to working on muscle cells, several muscle relaxants also affect neurons and the central nervous system (CNS).

Tendons connect the skeletal muscles, which control voluntary movement, to the bone. By producing chemicals (neurotransmitters) that energize the muscles, motor neurons allow for muscular contraction. 

Muscle spasms are caused by the abnormal firing of neurons which occurs because of certain disorders. Since antispasmodics and antispasmodics affect the central nervous system, older people may be particularly vulnerable to severe negative effects. 

The elderly are more likely to fall than a normal adult due to their unsteady gait, lack of muscle strength or coordination, and other age-related losses in mobility and cognition. 

Skeletal muscle relaxants can raise an elderly patient’s risk for falls and fractures since they frequently have the adverse effects of dizziness, sleepiness, and hypotension.

There have been studies conducted to determine the use of skeletal muscle relaxants. According to one study, the likelihood of injury increased with the use of certain muscle relaxants. 

Flexeril and ibuprofen interaction

Flexeril is a prescription drug for treating and curing lower back pain and other musculoskeletal disorders of varying degrees. Ibuprofen is a painkiller. 


The doctor is the best person to approach when one has questions about the usage of both Flexeril (cyclobenzaprine) and ibuprofen. The doctor should also be made aware of the medications that one takes before being prescribed these medications. 


The food interactions with cyclobenzaprine are moderate. Further details can be furnished by the physician. One must always be mindful of the amount of medication one is taking. 


It is advisable to go with the recommended dose prescribed by the physician. There is a chance that overuse could lead to severe side effects, and maybe even dependency. 


There is no sufficient information regarding flexeril and ibuprofen interaction. It is unclear whether cyclobenzaprine and ibuprofen are used together. It is best to consult a doctor who would specify if one requires both these medications.


There is no great benefit to combining both cyclobenzaprine and ibuprofen. Negative effects of the use of flexeril are seen in individuals with liver impairments. The use of flexeril is also not highly recommended for older people. 


Ibuprofen is a relatively safer medicine, but that does not mean that it does not have its risks. It could also cause liver impairments. The decrease in hepatic metabolism observed in elderly people can affect the expulsion of ibuprofen from their system. 

Therefore, combining both flexeril and ibuprofen could potentially cause problems for some people without providing much or any added benefit.